Bioperine, a natural bioenhancer derived from black pepper, has been the focus of various studies for its role in enhancing the bioavailability and efficacy of nutrients and therapeutic agents. This piperine extract is celebrated for its ability to increase the absorption of various compounds, thereby enhancing their health benefits and therapeutic potential.
One significant study explored the antineoplastic activity of a curcumin C3 complex combined with Bioperine in mesothelioma, providing in vitro and in vivo evidence of its efficacy in combating this challenging cancer (Di Meo et al., 2019). This research underscores the potential of Bioperine to enhance the anticancer properties of curcumin, offering hope for more effective treatment options for mesothelioma patients.
Furthermore, the impact of dietary supplementation with turmeric and curcumin, combined with Bioperine, on human gut microbiota has been investigated, revealing notable changes in the microbiome composition. This double-blind, randomized, placebo-controlled pilot study highlights the personalized nature of gut microbiota response to such supplementation, indicating that Bioperine may play a role in modulating gut health through its bioenhancement properties (Peterson et al., 2018).
In addition, a systematic review focused on the bioactive curcumin's effects on lowering systemic inflammation, as measured by CRP, found strong statistical significance for the C3 complex with Bioperine. This review further supports the role of Bioperine in augmenting the anti-inflammatory effects of curcumin, suggesting potential benefits for patients with conditions characterized by systemic inflammation (Katakowski & Hewlings, 2022).
These studies collectively highlight Bioperine's role in enhancing the bioavailability and efficacy of various compounds, from anticancer agents to anti-inflammatory substances. As research continues to unfold, Bioperine's potential in improving therapeutic outcomes and health benefits remains a promising area of exploration.
References
- Di Meo, F., Filosa, S., Madonna, M., Giello, G., Di Pardo, A., Maglione, V., Baldi, A., & Crispi, S. (2019). Curcumin C3 complex®/Bioperine® has antineoplastic activity in mesothelioma: an in vitro and in vivo analysis. Curcumin C3 complex®/Bioperine® has antineoplastic activity
- Peterson, C., Vaughn, A. R., Sharma, V., Chopra, D., Mills, P. J., Peterson, S. N., & Sivamani, R. K. (2018). Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study. Effects of Turmeric and Curcumin Dietary Supplementation
- Katakowski, L., & Hewlings, S. (2022). Bioactive Curcumin and its Effects on Lowering Systemic Inflammation as Measured by CRP: A Systematic Review. Bioactive Curcumin and its Effects on Lowering Systemic Inflammation
