Palmitoylethanolamide (PEA), a naturally occurring endocannabinoid-like compound, is highlighted for its multifaceted health benefits, particularly in supporting muscle and joint health. The review by Clayton et al. (2021) titled "Palmitoylethanolamide: A Natural Compound for Health Management" delves into the extensive anti-inflammatory, analgesic, antimicrobial, immunomodulatory, and neuroprotective effects of PEA. With its broad impact on various molecular targets and its ability to modulate multiple inflammatory mediators, PEA presents itself as a therapeutic powerhouse in lifestyle management and chronic disease mitigation.
The review emphasizes PEA's significant contributions towards enhancing immunity, brain health, allergy management, pain modulation, joint health, sleep quality, and recovery processes. Moreover, advancements in delivery systems have addressed its previously poor oral bioavailability, making it a compelling dietary supplement. The safety profile of PEA, marked by its tolerance and lack of side effects in both animals and humans, further underscores its potential as a vital component in health supplementation, particularly for individuals seeking to maintain or improve muscle and joint health.
References
- Clayton, P., Hill, M., Bogoda, N., Subah, S., & Venkatesh, R. (2021). Palmitoylethanolamide: A Natural Compound for Health Management. International Journal of Molecular Sciences, 22. Palmitoylethanolamide: A Natural Compound for Health Management